Abstract
Histoplasmosis is worldwide in distribution but is more prevalent in certain parts of North and Latin America. Histoplasma capsulatum var. capsulatum grows best in soil contaminated with bat or bird droppings. Patients often report exposure to microfoci-contaminated materials. Spores or mycelial fragments are inhaled and cause localized or patchy pneumonitis. Hematogenous dissemination to other tissues commonly follows during the first 2 weeks of infection before specific immunity has developed.
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References
Rippon JW: Histoplasmosis (Histoplasmosis capsulate). In Medical Mycology: The Pathogenic Fungi and the Pathogenic Actinomycetes. Edited by Wonsiewicz M. Philadelphia: WB Saunders; 1988: 381–423.
Wheat J: Histoplasmosis: experience during outbreaks in Indianapolis and review of the literature. Medicine 1997, 76: 339–354.
Brodsky AL, Gregg MB, Kaufman L, Mallison GF: Outbreak of histoplasmosis associated with the 1970 Earth Day activities. Am J Med 1973, 54: 333–342.
Ozols II, Wheat LJ: Erythema nodosum in an epidemic of histoplasmosis in Indianapolis. Arch Dermatol 1981, 117: 709–712.
Thornberry DK, Wheat LJ, Brandt KD, Rosenthal J: Histoplasmosis presenting with joint pain and hilar adenopathy: pseudosarcoidosis. Arthritis Rheum 1982, 25: 1396–1402.
Rosenthal J, Brandt KD, Wheat LJ, Slama TG: Rheumatologic manifestations of histoplasmosis in the recent Indianapolis epidemic. Arthritis Rheum 1983, 26: 1065–1070.
Wheat LJ, Stein L, Corya BC, et al.: Pericarditis as a manifestation of histoplasmosis during two large urban outbreaks. Medicine 1983 62: 110–119.
Coss KC, Wheat LJ, Conces DJ Jr, et al.: Esophageal fistula complicating mediastinal histoplasmosis: response to amphotericin B. Am J Med 1987, 83:343–346.
Wheat LJ, Wass J, Norton J, et al.: Cavitary histoplasmosis occurring during two large urban outbreaks: analysis of clinical, epidemiologic, roentgenographic, and laboratory features. Medicine 1984, 63:201–209.
Loyd JE, Tillman BF, Atkinson JB, des Prez RM: Mediastinal fibrosis complicating histoplasmosis. Medicine 1988, 67: 295–310.
Goodwin RA, Nickell JA, des Prez RM: Mediastinal fibrosis complicating healed primary histoplasmosis and tuberculosis. Medicine 1972, 51: 227–246.
Goodwin RA Jr, Shapiro JL, Thurman GH, et al.: Disseminated histoplasmosis: clinical and pathologic correlations. Medicine 1980, 59:1–33.
Wheat LJ, Slama TG, Norton JA, et al.: Risk factors for disseminated or fatal histoplasmosis. Ann Intern Med 1982, 96:159–163.
Sathapatayavongs B, Batteiger BE, Wheat LJ, et al.: Clinical and laboratory features of disseminated histoplasmosis during two large urban outbreaks. Medicine 1983, 62:263–270.
Wheat LJ, Connolly-Stringfield PA, Baker RL, et al.: Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature. Medicine 1990, 69:361–374.
Williams B, Fojtasek M, Connolly-Stringfield P, Wheat J: Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind. Arch Pathol Lab Med 1994, 1 18: 1205–1208.
Wheat LJ, Kohler RB, Tewari RP: Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens. N Engl J Med 1986, 314: 83–88.
Wheat LJ, Connolly-Stringfield P, Blair R. et al.: Histoplasmosis relapse in patients with AIDS: detection using Histoplasma capsulatum variety capsulatum antigen levels. Ann Intern Med 1991, 115:936–941.
Wheat LJ, French MLV, Kohler RB, et al.: The diagnostic laboratory tests for histoplasmosis: analysis of experience in a large urban outbreak. Ann Intern Med 1982, 97:680–685.
Wheat J. Hafner R, Korzun AH, et al.: Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. Am J Med 1995, 98:336–342.
Wheat J, MaWhinney S, Hafner R, et al.: Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. Am J Med 1997, 103:223–232.
Hecht FM, Wheat J, Korzun AH, et al.: Itraconazole maintenance treatment for histoplasmosis in AIDS: a prospective, multicenter trial. JAcquir Immune Defic Syndr Hum Retrovirol 1997, 16:100–107.
Wheat J, Hafner R, Wulfson M, et al.: Prevention of relapse of histoplasmosis with itraconazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1993, 118:610–616.
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Wheat, J. (2000). Histoplasmosis. In: Mandell, G.L., Diamond, R.D. (eds) Atlas of Infectious Diseases. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-9313-0_1
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DOI: https://doi.org/10.1007/978-1-4757-9313-0_1
Publisher Name: Current Medicine Group, London
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