Lipid-Lowering Drugs

  • Donald B. Hunninghake
  • Evan A. Stein


Lipid-lowering drugs are used primarily to reduce the risk of clinical events due to atherosclerotic vascular disease. Their use for both primary prevention (no prior clinical event) and secondary prevention (prior clinical event) of coronary heart disease (CHD) is now firmly established [1-6]. The majority of evidence for clinical benefit exists for the prevention of CHD. However, these drugs are also used in patients with clinical evidence of cerebrovascular or peripheral arterial disease because these patients have a high risk of CHD death and other events, and there is good evidence that the rate of progression of the atherosclerotic process can be delayed in both the carotid and peripheral arteries [3,6,7]. Furthermore, large and statistically significant reductions in stroke in patients with pre-existing CHD have been uniformly achieved in all the recent landmark trials [3,6,8,9].


Nicotinic Acid Coronary Heart Disease Risk National Cholesterol Education Program Bile Acid Sequestrant Lipid Research Clinic 
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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Donald B. Hunninghake
  • Evan A. Stein

There are no affiliations available

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