High-Density Lipoprotein Metabolism

  • H. Bryan BrewerJr.


High-density lipoprotein (HDL) cholesterol concentrations are inversely associated with coronary heart disease (CHD) in humans [1,2]. The initial descriptions of this inverse relationship in the early 1950s [3–5] were “rediscovered” in the 1970s [6–9]. The major mechanism proposed for the protective effect of HDL is reverse cholesterol transport, a process in which excess cholesterol from peripheral cells is transported back to the liver for removal from the body [10]. The higher the plasma levels of HDL, the more efficient is the transport to the liver of excess cholesterol from peripheral cells.


Cholesteryl Ester Transfer Protein Reverse Cholesterol Transport Tangier Disease Premature Cardiovascular Disease Cholesteryl Ester Transfer Protein Gene 
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© Springer Science+Business Media New York 2000

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  • H. Bryan BrewerJr.

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