Endothelial Dysfunction and Atherothrombosis

  • Noyan Gokce
  • Joseph Loscalzo


Located at the interface between the vessel wall and circulating blood, the vascular endothelium plays a critical role in the homeostatic and physiologic functions of the vasculature. In response to biochemical and mechanical stimuli, endothelial cells synthesize and elaborate a number of factors that modulate vascular tone, inflammation, thrombosis, and vascular growth. Normal endothelium provides a fluid antiatherogenic environment that inhibits platelet and leukocyte adhesion, prevents vasospasm, promotes fibrinolysis, and inhibits vascular smooth muscle cell growth. Under pathologic conditions when homeostatic mechanisms are altered, the phenotypic changes that occur in endothelial cells support a vasospastic, prothrombotic, and proinflammatory milieu, and play a central role in the pathophysiology and clinical manifestation of cardiovascular disease [1].


Nitric Oxide Endothelial Dysfunction Endothelial Function Intermittent Claudication Smooth Muscle Cell Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Noyan Gokce
  • Joseph Loscalzo

There are no affiliations available

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