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Histopathology of Arteriosclerosis

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Book cover Atlas of Atherosclerosis

Abstract

Both denuding and nondenuding endothelial injury have been proposed as pathogenetic mechanisms in atherogenesis. Conversion of a nondenuding injury to a denuding one, however, is not considered to be a rare event. Although both mechanisms initiate different molecular pathways, they ultimately lead to 1) proliferation of smooth muscle cells; 2) synthesis of connective tissue matrix; 3) focal accumulation of monocytes/macrophages; 4) lymphocytic infiltration; and 5) variable intracellular and extra-cellular lipid accumulation and eventually stenotic lesions [1].

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Authors
  1. Michael B. Gravanis
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Editors and Affiliations

  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Peter W. F. Wilson MD (Professor of Medicine, Director of Laboratories) (Professor of Medicine, Director of Laboratories)

  2. Framingham Heart Study, Framingham, Massachusetts, USA

    Peter W. F. Wilson MD (Professor of Medicine, Director of Laboratories) (Professor of Medicine, Director of Laboratories)

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© 2000 Springer Science+Business Media New York

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Gravanis, M.B. (2000). Histopathology of Arteriosclerosis. In: Wilson, P.W.F. (eds) Atlas of Atherosclerosis. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-9310-9_1

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  • DOI: https://doi.org/10.1007/978-1-4757-9310-9_1

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-9312-3

  • Online ISBN: 978-1-4757-9310-9

  • eBook Packages: Springer Book Archive

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