Rotavirus gastroenteritis is one of the major infectious diseases in the world today, as judged by mortality. Precise figures are not available, but it has been estimated that rotavirus diarrhea may take the lives of 500,000 or more children annually (Butler, 1984). Rotavirus diarrhea frequently results in dehydration and therefore runs a more severe course than do most other forms of infectious diarrhea in young children. While the share of rotavirus in all episodes of diarrhea in the developing countries is small, rotaviruses are much more frequently found among severe cases. A 2-year survey in Bangladesh showed that rotavirus to be responsible for 46% of the diarrheal episodes leading to dehydration (Black et al, 1981). In other etiologic studies of childhood diarrhea requiring hospital admission, rotavirus was found in 45% of cases in Costa Rica (Mata et al., 1983) and 49% in Ethiopia (Thorén et al., 1982).
KeywordsClinical Protection Primary Fetal Bovine Kidney Primary Monkey Kidney Cell Serologic Response Rate
Unable to display preview. Download preview PDF.
- Butler, T. C. (1984). J. Diarr. Dis. Res. 2, 137–141.Google Scholar
- Kapikian, A. Z., Midthun, K., Hoshino, Y., Flores, J., Wyatt, R. G., Glass, R. I., Askaa, J., Nakagomi, O., Nakagomi, T., Chanock, R. M., Levine, M. M., Clements, M. L., Dolin, R., Wright, P. F., Belshe, R. B., Anderson, E. L., and Potash, L. (1985). In Vaccines 85 (R. A. Lerner, R. M. Chanock, and F. Brown, eds.) pp. 357–367, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
- Kapikian, A. Z., Hoshino, Y., Flores, J., Midthun, K., Glas, R. I., Nakagomi, O., Chanock, R. M., Potash, L., Levine, M. M., Dolin, R., Wright, P. F., Belshe, R. E., Anderson, E. L., Vesikari, T., Gothefors, L., Wadell, G., and Perez-Schael, I. (1986). In Developments of Vaccines and Drugs against Diarrhea: Eleventh Nobel Conference (Stockholm) (J. Holmgren, A. Lindberg, R. Mölby, eds.), pp. 192–214, Student Litteratur, Lund.Google Scholar
- Mata, L., Simhon A., Padilla, R., Gamboa, M., Vargas, G., Hernandez, F., Mohs, E., and Lizano, C. (1983). J. Trop. Med. Hyg. 32, 146–153.Google Scholar
- Vesikari, T., Isolauri, E., André, F. E. (1986a). In Developments of Vaccines and Drugs against Diarrhea: Eleventh Nobel Conference (Stockholm) (J. Holmgren, A. Lindberg, R. Mölby, eds.), pp. 185–191, Student Litteratur, Lund.Google Scholar
- WHO (1984). Bull. WHO 62, 501–503.Google Scholar