The Development of New Poliovirus Vaccines Based on Molecular Cloning
Poliovirus, known since 1908 to be the causative agent of poliomyelitis (Paul, 1971), is a human enterovirus of the Picornaviridae. This virus consists of a single-stranded RNA of plus-strand polarity and 60 copies each of four capsid proteins, VP1, VP2, VP3, and VP4; it occurs in three serologically distinct types, i.e., type 1, type 2, and type 3.
KeywordsVaccine Strain Marker Test Infectious cDNA Clone Reference Virus Paralytic Poliomyelitis
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