New Analogues to Acyclovir with Increased Potency to Herpes Viruses
Acyclovir is highly active in vitro against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2, respectively), moderately active against varicella-zoster virus (VZV) and Eps-tein-Barr virus (EBV), and relatively inactive against cytomegalovirus (CMV). The full extent of the clinical value of acyclovir is still being defined, but we already know much about its efficacy and tolerance in a wide range of herpes virus infections. This has previously been discussed in a number of reviews, including Fiddian (1984), Fiddian et al. (1984), Rees and Fiddian (1985), and most recently Fiddian and Grant (1985).
KeywordsHerpes Simplex Virus Herpes Zoster Herpes Simplex Virus Infection Oral Acyclovir Intravenous Acyclovir
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- Balfour, H. H., Jr. (1986). In Clinical Advances in Antiviral Therapy (P. Lietman, S. Ohtani, and A. P. Fiddian, eds.), pp. 27–33, University of Tokyo Press, Tokyo, Japan.Google Scholar
- Fiddian, A. P., and Grant, D. M. (1985). Abs. Hyg. Commun. Dis. 60, R1–R22.Google Scholar
- King, D. H., and Fiddian, A. P. (1986). In Clinical Advances in Antiviral Therapy (P. Lietman, S. Ohtani, and A. P. Fiddian, eds.), pp. 65–71, University of Tokyo Press, Tokyo, Japan.Google Scholar
- Lundgren, G., Wilczek, H., Lönnqvist, B., Lindholm, A., Wahren, B., and Ringden, O. (1985). Scand. J. Infect. Dis. (Suppl) 47, 137–144.Google Scholar
- McGill, J., MacDonald, D. R., Fall, C., McKendrick, G. D. W., and Copplestone, A. (1983). J. Infect. Dis. 6, 157–161.Google Scholar
- McKendrick, M. W. (1985). Scand. J. Infect. Dis. (Suppl) 47, 76–79.Google Scholar
- Masur, H., Lane, C., Palestine, A., Smith, P. D., Manischewitz, J., Stevens, G., Fujikawa, L., Macher, A. M., Nussenblatt, R., Baird, B., McGill, M., Wittek, A., Quinnan, G. V., Parrillo, J. E., Rook, A. H., Eron, L. J., Poretz, D. M., Goldenberg, R. I., Fauci, A. S., and Gelmann, E. P. (1986). Ann. Intern. Med. 104, 41–44.PubMedCrossRefGoogle Scholar
- Meyers, J. D. (1985). Scand. J. Infect. Dis. (Suppl.) 47, 128–136.Google Scholar
- Rees, P. J., and Fiddian, A. P. (1985). J. Drug Ther. Res. 10, 637–640.Google Scholar