Abstract
The first results of active immunization against hepatitis B in humans were reported a little over 10 years ago (Maupas et al., 1976). Since then, several serum-derived hepatitis B (HB) vaccines have been proved safe, highly immunogenic and efficacious in various populations at risk (Stevens et al., 1984). However, the high cost of production has limited their use to high-risk volunteers in developed countries. Even there, it has been found difficult to expand immunization to all exposed individuals. In France, for instance, immunization of the estimated 1.5 million individuals at risk would cost around $100 million, i.e., 10-fold the cost of the entire rubella-prevention program. Endemic areas in which large-scale use of HB vaccines would be the most valuable are in Africa or Southeast Asia. Many countries in these areas simply cannot afford hepatitis B immunization unless prices of vaccines are significantly lowered. With currently available vaccines, immunization can be achieved by two means: (1) reducing the number of doses for primary immunization, and (2) lowering the concentration of HB s Ag in the vaccine.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barin, F., Goudeau, A., Denis, F., Yvonnet, B., Chiron, J. P., Coursaget, P., and Diop Mar, I. (1982). Lancet 1, 251ā253.
Chiron, J. P., Coursaget, P., Yvonnet, B., Auger, F., Lee Quan, T., Barin, F., Denis, F., and Diop Mar, I. (1984). Lancet 1, 623ā624.
Crosnier, J., Jungers, P., Courouce, A. M., Laplanche, A., Benhamou, E., Degos, F., LaCour, B., Prunet, P., Cerisier, Y., and Guesry, P. (1981). Lancet 1, 455ā458; 797-800.
Goudeau, A., Dubois, F., Barin, F., Dubois, M. C., and Coursaget, P. (1983). Dev. Biol. Stand. 54, 267ā284.
Goudeau, A., Dubois, F., Jeussray, B., DuBois, M. C., Louq, C., Mazert, M. C., and Tron, F. (1984a). Proceedings of the IASL-EASL Symposium, Bern.
Goudeau, A., Dubois, F., Dubois, M. C., Louq, C., and Mazert, M. C. (1984b). Lancet 2, 1091.
Maupas, P., Goudeau, A., Coursaget, P., Drucker, J., and Bagros, P. (1976). Lancet 1, 1367ā1370.
Maupas, P., Chiron, J. P., Barin, F., Coursaget, P., Goudeau, A., Perrin, J., Denis, F., and Diop Mar, I. (1981). Lancet 1, 289ā292.
Mazert, M. C., Chabanier, G., Adamowicz, P., and Gerfaux, G. (1983). Dev. Biol. Stand. 54, 53ā62.
Perrin, J., Ntareme, F., Coursaget, P., and Chiron, J. P. (1985). In Virus-Associated Cancers in Africa (A. O. Williams, G. T. OāConnor, and G. B. de The, C. A. Johnson, eds.), pp. 307ā318, IARC., Lyons.
Piazza, M., Picciotto, L., Willari, R., Guadagnino, V., Orlando, R., Isabella, L., Macchia, V., Memoli, A. M., Vegnente, A., Borelli, A. M., Scarcella, A., Cascioli, C., Cirrilo, C., Coppola, P., Isabella, E., and Parisi, G. (1985a). Lancet 1, 949ā951.
Piazza, M., Piccioto, L., Villari, R., Guadagnino, V., Orlando, R., Macchia, V., Memoli, A. M., Vegnente, A., Guida, S., and Fusco, C. (1985b). Lancet 2, 1120ā1121.
Stevens, C. E., Taylor, P. E., Tong, M. J., Toy, P. T., and Vyas, G. N. (1984). In Virale Hepatitis and Liver Disease (G. N. Vyas, J. L. Dienstag, and J. H. Hoffnagle, eds.), pp. 275ā291, Grune & Stratton, Orlando, Florida.
Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Olesko, W. R., William, D. C., Sadovsky, R., Morrison, J. M., and Kellner, A. (1980). N. Engl. J. Med. 303, 833ā841.
Yvonnet, B., Coursaget, P., Petat, E., Tortey, E., Diouf, C., Barin, F., Denis, F., Diop Mar, I., and Chiron, J. P. (1984). J. Med. Virol. 14, 137ā139.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Goudeau, A. et al. (1988). Hepatitis B Vaccine. In: Kurstak, E., Marusyk, R.G., Murphy, F.A., Van Regenmortel, M.H.V. (eds) New Vaccines and Chemotherapy. Applied Virology Research, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9268-3_16
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9268-3_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9270-6
Online ISBN: 978-1-4757-9268-3
eBook Packages: Springer Book Archive