Rabies Vaccine Potency and Stability Testing
It is 100 years since Louis Pasteur carried out the first immunization of humans against rabies virus infection. Although great advances have been made in the development of more effective and purified vaccines, vaccines produced in adult or suckling animal nervous tissue are still in use in many countries. Cell culture systems now used for the production of human rabies vaccines include human diploid cell strain (HDCS), primary chick embryo fibroblasts, Vero cells, primary hamster, and dog or fetal bovine kidney cells.
KeywordsRabies Virus Rabies Vaccine Potency Estimate Rabies Virus Infection Rabies Virus Glycoprotein
Unable to display preview. Download preview PDF.
- Cox, J. H., Dietzschold, B., and Schneider, L. G. (1977). Infection Immun. 16, 754–759.Google Scholar
- Finney, D. J. (1978). Statistical Methods in Biological Assay, 3rd ed., Griffin, London.Google Scholar
- Kirkwood, T. B. (1979). Biometrics 35, 908–909.Google Scholar
- Seligman, E. B., Jr. (1973). In Laboratory Techniques in Rabies, 3rd ed. (M. M. Kaplan and H. Koprowski, eds.), WHO, Geneva.Google Scholar
- World Health Organization (1979). Tech. Rep. Ser. 638, 15.Google Scholar
- World Health Organization (1981). Tech. Rep. Ser. 658, 54–95.Google Scholar
- World Health Organization (1983). Tech. Rep. Ser. 700, 15.Google Scholar