Rabies Vaccine Potency and Stability Testing

Applications of Single-Radial Immunodiffusion Methods
  • Morag Ferguson
  • Valerie Seagroatt
  • G. C. Schild
Chapter
Part of the Applied Virology Research book series (AOTP, volume 1)

Abstract

It is 100 years since Louis Pasteur carried out the first immunization of humans against rabies virus infection. Although great advances have been made in the development of more effective and purified vaccines, vaccines produced in adult or suckling animal nervous tissue are still in use in many countries. Cell culture systems now used for the production of human rabies vaccines include human diploid cell strain (HDCS), primary chick embryo fibroblasts, Vero cells, primary hamster, and dog or fetal bovine kidney cells.

Keywords

Rabies Virus Rabies Vaccine Potency Estimate Rabies Virus Infection Rabies Virus Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Atanasiu, P., Perrin, P., Delagneau, J. F., Versmisse, P., Chevallier, G., Reculard, P., Le Fur, R., Sureau, P. (1982). J. Biol. Stand. 10, 289–296.PubMedCrossRefGoogle Scholar
  2. Barth, R., Gross-Albenhausen, E., Jaeger, O., and Milcke, L. (1981). J. Biol. Stand. 9, 81–99.PubMedCrossRefGoogle Scholar
  3. Cox, J. H., Dietzschold, B., and Schneider, L. G. (1977). Infection Immun. 16, 754–759.Google Scholar
  4. Ferguson, M., and Schild, G. C. (1982). J. Gen. Virol. 59, 197–201.PubMedCrossRefGoogle Scholar
  5. Ferguson, M., Seagroatt, V., and Schild, G. C. (1984). J. Biol. Stand. 12, 283–294.PubMedCrossRefGoogle Scholar
  6. Finney, D. J. (1978). Statistical Methods in Biological Assay, 3rd ed., Griffin, London.Google Scholar
  7. Kirkwood, T. B. (1979). Biometrics 35, 908–909.Google Scholar
  8. Schild, G. C., Wood, J. M., and Newman, R. W. (1975). Bull. WHO 52, 223–231.PubMedGoogle Scholar
  9. Seligman, E. B., Jr. (1973). In Laboratory Techniques in Rabies, 3rd ed. (M. M. Kaplan and H. Koprowski, eds.), WHO, Geneva.Google Scholar
  10. van der Marel, P., and van Wezel, A. L. (1981). Dev. Biol. Stand. 50, 267–275.PubMedGoogle Scholar
  11. Wood, J. M., Schild, G. C., Newman, R. W., and Seagroatt, V. (1977). J. Biol. Stand. 5, 237–247.PubMedCrossRefGoogle Scholar
  12. Wood, J. M., Seagroatt, V., Schild, G. C., Mayner, R. E., and Ennis, F. (1981). J. Biol. Stand. 9, 317–330.PubMedCrossRefGoogle Scholar
  13. World Health Organization (1979). Tech. Rep. Ser. 638, 15.Google Scholar
  14. World Health Organization (1981). Tech. Rep. Ser. 658, 54–95.Google Scholar
  15. World Health Organization (1983). Tech. Rep. Ser. 700, 15.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Morag Ferguson
    • 1
  • Valerie Seagroatt
    • 1
  • G. C. Schild
    • 1
  1. 1.National Institute for Biological Standards and ControlPotters Bar, HertsEngland

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