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The Molecular Genetics of Hepatitis C Virus (HCV) and its Use in the Diagnosis of HCV Infections

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Applied Virology Research

Part of the book series: Applied Virology Research ((AVIR,volume 3))

Abstract

The genome of one of the causative agents of non-A, non-B (NANB) hepatitis was discovered by Choo et al., (1989) using re-combinant complementary DNA (cDNA) technology. This agent, now known as hepatitis C virus (HCV), is known to be the predominant cause of post-transfusion NANB hepatitis worldwide (Alter et al., 1989; Esteban et al.,1989; Kuo et al., 1989; Van der Poel et al., 1989; Choo et al., 1990; Kurstak, 1993). Anti-HCV has been associated with most cases of hepatocellular carcinoma (HCC) in Italy (Colombo et al., 1989), Spain (Bruix et al., 1989) and Japan (Nishioka et al., 1991). HCV thus appears to be a major etiological agent of NANB hepatitis, chronic liver disease and HCC around the globe. This review focuses on the molecular biology of HCV and its utilization in the diagnosis of hepatitis C virus disease.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

    Edouard Kurstak, Christine Kurstak & A. Hossain

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  1. Edouard Kurstak
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  2. Christine Kurstak
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  3. A. Hossain
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Editors and Affiliations

  1. Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

    Edouard Kurstak

  2. University of Alberta, Edmonton, Alberta, Canada

    R. G. Marusyk

  3. University of California, Davis, California, USA

    F. A. Murphy

  4. Institute of Molecular and Cellular Biology, Strasbourg, France

    M. H. V. Van Regenmortel

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Kurstak, E., Kurstak, C., Hossain, A. (1994). The Molecular Genetics of Hepatitis C Virus (HCV) and its Use in the Diagnosis of HCV Infections. In: Kurstak, E., Marusyk, R.G., Murphy, F.A., Van Regenmortel, M.H.V. (eds) Applied Virology Research. Applied Virology Research, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9265-2_4

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  • DOI: https://doi.org/10.1007/978-1-4757-9265-2_4

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