The Molecular Genetics of Hepatitis C Virus (HCV) and its Use in the Diagnosis of HCV Infections

  • Edouard Kurstak
  • Christine Kurstak
  • A. Hossain
Part of the Applied Virology Research book series (AVIR, volume 3)


The genome of one of the causative agents of non-A, non-B (NANB) hepatitis was discovered by Choo et al., (1989) using re-combinant complementary DNA (cDNA) technology. This agent, now known as hepatitis C virus (HCV), is known to be the predominant cause of post-transfusion NANB hepatitis worldwide (Alter et al., 1989; Esteban et al.,1989; Kuo et al., 1989; Van der Poel et al., 1989; Choo et al., 1990; Kurstak, 1993). Anti-HCV has been associated with most cases of hepatocellular carcinoma (HCC) in Italy (Colombo et al., 1989), Spain (Bruix et al., 1989) and Japan (Nishioka et al., 1991). HCV thus appears to be a major etiological agent of NANB hepatitis, chronic liver disease and HCC around the globe. This review focuses on the molecular biology of HCV and its utilization in the diagnosis of hepatitis C virus disease.


Polymerase Chain Reaction Assay NANB Hepatitis Liquid Hybridization Chronic NANB Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Edouard Kurstak
    • 1
  • Christine Kurstak
    • 1
  • A. Hossain
    • 1
  1. 1.Department of Microbiology and Immunology, Faculty of MedicineUniversity of MontrealMontrealCanada

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