Radiolabeled Antibodies: Introduction and Metal Conjugation Techniques

  • Sally W. Schwarz
  • Michael J. Welch
Part of the Industry-University Cooperative Chemistry Program Symposia book series (IUCC)


The use of radiolabeled antibodies in the detection and treatment of cancer has been in practice since the early 1980’s. Radioimmunoimaging is an in vivo diagnostic technique where a radiolabeled antibody is taken up or bound to an antigen in a target tissue. This allows for non-invasive imaging of the antigen containing tissue, using a gamma camera or a positron emission tomograph (PET) scanner, for subsequent therapy or resection of the tissue if necessary. Radioimmunotherapy is the delivery of a therapeutic quantity of a radioisotope to the same antigen containing tissue to ablate or reduce a primary or metastatic carcinoma. This chapter will cover the basic principles of antibodies, subsequent conjugation with bifunctional chelates and radiolabeling for the purpose of radioimmunoimaging or radioimmunotherapy.


Myeloma Cell Positron Emission Tomograph Cardiac Myosin Absorb Radiation Dose Cyclic Anhydride 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Sally W. Schwarz
    • 1
  • Michael J. Welch
    • 1
  1. 1.Mallinckrodt Institute of RadiologyWashington UniversitySt. LouisUSA

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