Apoptosis pp 97-115 | Cite as

Ion Signalling in Apoptosis

  • Pierluigi Nicotera
  • Boris Zhivotovsky
  • Giorgio Bellomo
  • Sten Orrenius
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)


Apoptosis (Kerr et al., 1972; Wyllie et al., 1980), a genetically controlled cell deletion process modulates organ development (Ellis and Horvitz, 1986) and immune cell ontogenesis (Smith et al., 1989) in a predestined fashion. In the adult organism, the apoptotic program is activated to kill neoplastic cells (Trauth et al., 1989) influencing the rate of tumor cell population expansion (Arends and Wyllie, 1991). On the other hand, apoptosis can be evoked in a number of pathological states. Thus, immuno-competent cells are inappropriately eliminated by apoptosis in HIV infection (Groux et al., 1992), whereas viruses (Rao et al., 1992) and bacterial toxins (Fiorentini et al, 1993) can directly elicit an apoptotic response in target cells. Finally, exposure to ionizing radiation (Zhivotovsky et al., 1981 and 1993b) or chemical toxicants (McConkey et al., 1988; Aw et al., 1990) can accelerate apoptosis in immature T cells.


Apoptotic Body Endonuclease Activation Chromatin Loop Thymocyte Apoptosis Apoptotic Body Formation 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Pierluigi Nicotera
    • 1
  • Boris Zhivotovsky
    • 1
  • Giorgio Bellomo
    • 2
  • Sten Orrenius
    • 1
  1. 1.Institute of Environmental Medicine, Division of ToxicologyKarolinska InstituteStockholmSweden
  2. 2.Department of Experimental Medicine and Oncology, Institute of General PathologyUniversity of TorinoTorinoItaly

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