Apoptosis pp 85-96 | Cite as

Regulation of Apoptosis in Interleukin-3-Dependent Myeloid Progenitor Cells

  • John L. Cleveland
  • David S. Askew
  • Concha Bello-Fernandez
  • Graham Packham
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)


Apoptosis plays an important role in the regulation of hematopoiesis by deleting growth factor-dependent progenitors following physiologic reductions in hemopoietins.1,2 To examine signalling pathways which may influence apoptosis in hematopoietic progenitors we have utilized the Interleukin-3 (IL-3) dependent 32Dcl3 murine myeloid cell line. 32D cells are absolutely dependent upon IL-3 for proliferation and survival,3,4 and have no propensity for developing factor-independent growth. In the absence of IL-3, 32D cells rapidly arrest in the Gl phase of the cell cycle and eventually undergo apoptosis.5


Ornithine Decarboxylase Myeloid Progenitor Cell Promote Cell Cycle Progression Progenitor Cell Line Polyamine Pool 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • John L. Cleveland
    • 1
  • David S. Askew
    • 1
  • Concha Bello-Fernandez
    • 1
  • Graham Packham
    • 1
  1. 1.Department of BiochemistrySt. Jude Children’s Research HospitalMemphisUSA

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