C-MYC: Oncogene and Tumour Suppressor Gene
Eukaryotic cell proliferation in metazoans is regulated by a variety of positive and negative signals that serve to rigidly control cell division. This underscores a major problem facing multicellular organisms: namely, how to allow the rapid proliferation of component cells and at the same time never allow those component cells to engage in competition with each other. In principle, any cell that acquires a growth advantage through mutation should out-compete its siblings and generate a hyperplastic clone from which ever more rapidly proliferating mutants are likely to arise. Such an event is, however, extremely rare as demonstrated by the fact that cancer arises in only one in three individuals during the entire course of their lives. Part of the answer to this paradox appears to reside in the multifunctional nature of the components that mediate cell proliferation. One of these, c-Myc, is the subject of this paper.
KeywordsSister Cell Early Growth Response Gene Primary Vascular Smooth Muscle Cell Eukaryotic Cell Proliferation
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