Apoptosis pp 47-62 | Cite as

Regulation of Apoptosis by the Transforming Gene Products of Adenovirus

  • Eileen White
  • Lakshmi Rao
  • Shiun-Kwei Chiou
  • Ching-Chun Tseng
  • Peter Sabbatini
  • Michelle Gonzalez
  • Philippe Verwaerde
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)


The DNA tumor virus adenovirus infects human cells, recruits them into a proliferative state, and borrows elements of the host cell transcription, translation, and DNA replication machinery to reproduce viral proteins and DNA. In rodent cells which are semipermissive for adenovirus infection, cell growth is deregulated but virus replication is ineffective. As the viral infection does not progress to completion, the deregulation of cell growth control produces transformation. The viral genes required for oncogenic transformation are the E1A and E1B oncogenes.


HeLa Cell Human Papilloma Virus Cell Growth Control Infected Human Cell SV40 Large Tumor Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Eileen White
    • 1
  • Lakshmi Rao
    • 1
  • Shiun-Kwei Chiou
    • 1
  • Ching-Chun Tseng
    • 1
  • Peter Sabbatini
    • 1
  • Michelle Gonzalez
    • 1
  • Philippe Verwaerde
    • 1
  1. 1.Center for Advanced Biotechnology and Medicine, Department of Biological SciencesRutgers UniversityPiscatawayUSA

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