Apoptosis pp 223-236 | Cite as

Induction of Apoptosis by Cell-Cycle Phase Specific Drugs

  • Steven W. Sherwood
  • Robert T. Schimke
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)


The events of apoptosis represent the outcome of processes defining a common physiological pathway of dying cells, and the inputs to this pathway are complex and highly varied1–5. It is clear that the actions of cytotoxic agents in mammalian cells frequently feed into the apoptosis pathway, and an extremely wide variety of agents/treatments have been shown to induce the events of apoptosis in cultured mammalian cells6,7. It is important to note, however, that cells vary widely in responses to specific cytotoxic agents and the induction of apoptosis by a given agent can vary between cell lines.


Cell Cycle HeLa Cell Cell Cycle Phase Mitotic Arrest Mitotic Checkpoint 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Steven W. Sherwood
    • 1
  • Robert T. Schimke
    • 1
  1. 1.Department of Biological SciencesStanford UniversityStanfordUSA

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