Regulation of Cell Growth by Transcription Factors, IRF-1 and IRF-2
Cytokine transmit signals to cell interior, resulting in the activation/repression of the genes critical for cell growth and differentiation. One class of cytokines is the interferons (IFNs), which represent a heterogeneous family of multifunctional cytokines that typically manifest antiviral activity. In fact, viral infections commonly trigger induction of the type-I IFN (IFN-αs and IFN-β) genes in a variety of cells, and these newly produced IFNs can, in turn, activate a set of IFN-inducible genes. IFNs also exhibit anti-proliferative effects on many normal and transformed cells1‘2. In addition, it has been reported that one of the IFN species, IFN-γ, plays a critical role in induced cell death of effector T lymphocyte3.
KeywordsOligoadenylate Synthetase Steady State Expression Human Interferon Regulatory Factor
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