Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans
Naturally-occurring or “programmed” cell death appears to be a universal aspect of animal development (e.g., Ref. 1). For example, massive cell death occurs during the development of the mammalian fetus, particularly in the fetal brain; in areas of the developing vertebrate nervous system as many as 85% of the developing neurons die. Similarly, about 95% of developing thymocytes die without ever leaving the thymus. Why such cell deaths occur and how they are regulated are fundamental problems in developmental biology.
KeywordsAmyotrophic Lateral Sclerosis Motor Neuron Caenorhabditis Elegans Ventral Nerve Cord Program Cell Death
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