Apoptosis pp 1-13 | Cite as

Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

  • H. Robert Horvitz
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)


Naturally-occurring or “programmed” cell death appears to be a universal aspect of animal development (e.g., Ref. 1). For example, massive cell death occurs during the development of the mammalian fetus, particularly in the fetal brain; in areas of the developing vertebrate nervous system as many as 85% of the developing neurons die. Similarly, about 95% of developing thymocytes die without ever leaving the thymus. Why such cell deaths occur and how they are regulated are fundamental problems in developmental biology.


Amyotrophic Lateral Sclerosis Motor Neuron Caenorhabditis Elegans Ventral Nerve Cord Program Cell Death 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • H. Robert Horvitz
    • 1
  1. 1.Howard Hughes Medical Institute, Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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