Treatment of Acyclovir-Resistant Herpes Simplex and Varicella Zoster Virus Infections

  • Sharon Safrin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 394)


Acyclovir-resistant HSV (ACV-R-HSV) infections were first described in 1982.1 To date, over 100 patients with ACV-R-HSV infection have been identified. Although in vitro resis10 tance to acyclovir has been demonstrated in isolates recovered from immunocompetent hosts,2 for practical purposes only the severely immunocompromised patient develops clinically significant ACV-R-HSV (e.g. patients with AIDS, hematologic malignancies, congenital immune deficiencies, or those who have undergone organ transplantation3–9). The single exception to date is a report by Kost et al. of an HIV-negative immunocompetent man with increasingly frequent recurrences of genital HSV despite the use of maximal doses of oral acyclovir for suppression or for treatment.10 This patient, however, appeared to have acquired ACV-R-HSV infection through direct transmission, having had in the recent past 3 new sexual partners of whom 2 had HIV infection.


Herpes Simplex Virus Acquire Immunodeficiency Syndrome Herpes Simplex Virus Infection Oral Acyclovir Acyclovir Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1996

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  • Sharon Safrin

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