Subclinical Shedding of HSV: Its Potential for Reduction by Antiviral Therapy

  • Lawrence Corey
  • Anna Wald
  • L. Gray Davis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 394)

Abstract

Several recent serosurveys have indicated that the prevalence of HSV-2 infection is continuing to increase (Table 1)1–5. The prevalence of HSV-2 is high in many populations. In Seattle, 43% of women and 35% of men attending STD clinics have already acquired HSV-2 infection, while in British STD clinic attendees, the figures are 37% and 27%. Breinig et al reported that 21% of women attending family planning clinics were HSV-2 seropositive3. Perhaps the most definitive work in this area is a recent population based serosurvey of the US adults which has shown that the overall seroprevalence of HSV-2 has risen from 16.4% in 1978 to 21.7% in 1990; a 32% increase in HSV-2 seropositivity in the last decade6.

Keywords

Genital Herpes South CarolIna Genital Lesion Penile Skin Recurrent Genital Herpes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Nahmias M, Lee FK, Beckman-Nahmias S. Seroepidemiological and sociological patterns of herpes simplex virus infection in the world. Scand J Infect Dis Suppl 1990; 69: 19036.Google Scholar
  2. 2.
    Ashley R. Herpes simplex virus, In: Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. 75h Edition, Ed: E. Lennette. Amer Public Health Assoc., Washington, D.C. (In Press)Google Scholar
  3. 3.
    Breinig MK, Kingsley LA, Armstrong JA, Freeman DJ, Ho M. Epidemiology of genital herpes in Pittsburgh: serologic, sexual, and racial correlates of apparent and inapparent herpes simplex infection. J Infect Dis 1990; 162: 299–305.PubMedCrossRefGoogle Scholar
  4. 4.
    Johnson RE, Nahmias AJ, Magder LS, Lee FK, Brooks CA, Snowden CB. A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 infection in the United States. N Engl J Med 1990; 321: 712.Google Scholar
  5. 5.
    Corey L. The current trend in genital herpes. Progress in prevention. Sex Trans Dis 1994; 21 (Suppl 2): S38 - S44.Google Scholar
  6. 6.
    Johnson R, Lee F, Hadgu A, McQuillan G, Aral S, Keesling S. Nahmias A. US genital herpes trends during the first decade of AIDS - prevalences increased in young whites and elevated in blacks. Abstract. Tenth International Society for STD Research, Helsinki, Finland, August 29-Sept. 1, 1993.Google Scholar
  7. 7.
    Wald A, Zeh J, Selke S. Ashley RL, Corey L. Subclinical genital herpes has similar virologie characteristics as symptomatic genital herpes. N Engl J Med 1995; 333: 770–775.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Lawrence Corey
  • Anna Wald
  • L. Gray Davis

There are no affiliations available

Personalised recommendations