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Antimicrobial Resistance pp 49–57Cite as

Bacterial Resistance to Fluoroquinolones: Mechanisms and Patterns

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 390))

Abstract

Fluoroquinolones have been used increasingly in clinical medicine in the United States since the approval of norfloxacin, the first of these agents, by the U.S. Food and Drug Administration in 1986. Approvals of ciprofloxacin, ofloxacin, temafloxacin, lomefloxacin, and enoxacin followed, and other fluoroquinolones are under development. Although a nonfluorinated quinolone, nalidixic acid, has been available since the 1960s, its use was limited to treatment of urinary tract infections. Because of their greater potency and spectrum of activity and their extensive tissue distribution, many of the fluoroquinolones have been used to treat a broad range of infections at different body sites. Because of economic pressures, it is likely that oral antibiotics like the fluoroquinolones will be relied on increasingly in the future.

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Authors and Affiliations

  1. Infectious Disease Unit, Massachusetts General Hospital, Boston, MA, 02114-2696, USA

    David C. Hooper M.D.

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  1. David C. Hooper M.D.
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Editors and Affiliations

  1. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    Donald L. Jungkind

  2. St. Christopher’s Hospital for Children, Philadelphia, Pennsylvania, USA

    Joel E. Mortensen

  3. The Graduate Hospital, Philadelphia, Pennsylvania, USA

    Henry S. Fraimow

  4. Merck Research Laboratories, West Point, Pennsylvania, USA

    Gary B. Calandra

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Hooper, D.C. (1995). Bacterial Resistance to Fluoroquinolones: Mechanisms and Patterns. In: Jungkind, D.L., Mortensen, J.E., Fraimow, H.S., Calandra, G.B. (eds) Antimicrobial Resistance. Advances in Experimental Medicine and Biology, vol 390. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9203-4_4

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  • DOI: https://doi.org/10.1007/978-1-4757-9203-4_4

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