Resistance to Antibacterial Agents

  • Christine C. Sanders
  • W. Eugene SandersJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 390)


There are three major mechanisms whereby bacteria initially susceptible to an antimicrobial agent may acquire the ability to resist the effects of this agent. These include prevention of intracellular drug accumulation, alteration in the target of the drug, and production of a drug-inactivating enzyme. The relative importance of each of these mechanisms varies depending upon the organism involved, the antimicrobial agent, and the location of the target of the antimicrobial agent within the bacterial cell (Table 1).


Antimicrobial Agent Outer Membrane Cytoplasmic Membrane Periplasmic Space Lactam Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Christine C. Sanders
    • 1
  • W. Eugene SandersJr.
    • 1
  1. 1.Center for Research in Anti-Infectives and Biotechnology Department of Medical MicrobiologyCreighton University School of MedicineOmahaUSA

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