Resistance to Antibacterial Agents
There are three major mechanisms whereby bacteria initially susceptible to an antimicrobial agent may acquire the ability to resist the effects of this agent. These include prevention of intracellular drug accumulation, alteration in the target of the drug, and production of a drug-inactivating enzyme. The relative importance of each of these mechanisms varies depending upon the organism involved, the antimicrobial agent, and the location of the target of the antimicrobial agent within the bacterial cell (Table 1).
KeywordsAntimicrobial Agent Outer Membrane Cytoplasmic Membrane Periplasmic Space Lactam Antibiotic
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