Abstract
The study of biochemical and genetic aspects of antibiotic production is of great interest because it casts light on the mechanisms of cellular differentiation. It is also important for two practical reasons: the improvement of production yields and the possibility of directing the fermentation process toward products with desired characteristics.
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Chapter 6. Biosynthesis and Genetics of Antibiotic Production
Baltz, R. H., Hegeman, G. D., and Skatrud, P. L. (eds.), 1993, Industrial Microorganisms: Basic and Applied Molecular Genetics, American Society for Microbiology, Washington, D.C.
Corcoran, J. W. (ed.), 1981, Antibiotics IV: Biosynthesis, Springer-Verlag, Berlin. Floss, H. G., and Beale, J. M., 1989, Biosynthetic studies on antibiotics, Angew. Chem. Int. Ed. Engl. 28: 146.
Hershberger, C. L., Queener, S. W., and Hegeman, G. (eds.), 1989, Genetics and Molecular Biology of Industrial Microorganisms, American Society for Microbiology, Washington, D.C.
Horinouchi, S., and Beppu, T., 1992, Autoregulatory factors and communication in actinomycetes, Annu. Rev. Microbial. 46: 377.
Lancini, G. C., and Lorenzetti, R., 1993 Biotechnology of Antibiotics and Other Microbial MetabolitesPlenum Press, New York.
Pape, H., and Rehm, FI. J. (eds.), 1986, Biotechnology,Vol. 4: Microbial Products 1I,VCH Verlag, Weinheim.
Vandamme, E. J. (ed.), 1984 Biotechnology of Industrial AntibioticsDekker, New York. Vining, L. C. (ed.), 1983 Biochemistry and Genetic Regulation of Commercially Important AntibioticsAddison–Wesley, Reading, Mass.
Aharonowitz, Y., Cohen, G., and Martin, J. F., 1992, Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation, and evolution, Annu. Rev. Microbiol. 46: 461.
Donadio, S., Stayer, M. J., McAlpine, J. B., Swanson, S. J., and Katz, L., 1991, Modular organization of genes required for complex polyketide biosynthesis, Science 252: 675.
Doull, J., Ahmed, Z., Stuttard, C., and Vining, L. C., 1985, Isolation and characterization of Streptomyces venezuelae mutants blocked in chloramphenicol biosynthesis, J. Gen. Microbiol. 131: 97.
Ebersole, R. C., Godfredsen, W. O., Vangedal, S., and Caspi, E., 1973, Mechanism of oxidative cyclization of squalene. Evidence for cyclization of squalene from either end of squalene molecule in the in vivo biosynthesis of fusidic acid by Fusidium coccineum, J. Am. Chem. Soc. 95: 8133.
Elson, S. W., Baggaley, K. H., Davison, M., Fulstone, M., Nicholson, N. H., Risbridger, G. D., and Tyler, J. W., 1993, The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway, J. Chem, Soc., Client. Commun. 1993: 1212.
Harris, C. M., Roberson, J. S., and Harris, T. M., 1976, Biosynthesis of griseofulvin J. Am. Chem. Soc. 98:5380.
Isono, K., 1988, Nucleoside antibiotics: Structure, antibiotic activity and biosynthesis J. Antibiot. 41:1711.
Jung, G., 1991, Lantibiotics—Ribosomally synthesized biologically active polypeptides containing sulfide bridges and u-13-didehydroamino acids, Angeza. Chem. Int. Ed. Engl. 30: 1051.
Kakinuma, K., Ogawa, Y., Sakasi, T., Seto, H., and Otake, N., 1989, Mechanism and stereochemistry of the biosynthesis of 2-deoxystreptamine and neosamine C, J. Antibiot. 42: 926.
Katz, L., and Donadio, S., 1993, Polyketide synthesis: Prospects for hybrid antibiotics Annu. Rev. Microbiol. 47:875.
Kleinkauf, H., and von Döhren, H., 1987, Biosynthesis of peptide antibiotics Annu. Rev. Microbiol. 41:259.
Kuo, M. S., Yurek, D. A., Coats, J. H., Chung, S. T., and Li, G. P., 1992, Isolation and identification of 3-propylidene-A-pyrroline-5-carboxylic acid, a biosynthetic precursor of lincomycin, J. Antibiot. 45: 1773.
Lacalle, R. A., Tercero, J. A., and Jiménez, A., 1992, Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts, EMBO J. 11: 785.
Lancini, G. C., 1986, Ansamycins, in Biotechnology, Vol. 4: Microbial Products II ( H. Pape and H.-J. Rehm, eds.), pp. 431–463, VCH Verlag, Weinheim.
Lancini, G. C., 1989, Fermentation and biosynthesis of glycopeptide antibiotics, Prog. Ind. Microbiol. 27: 283.
Martin, J. F., 1984, Biosynthesis, regulation and genetics of polyene macrolide antibiotics, in Macrolide Antibiotics ( S. Omura, ed.), pp. 405–424, Academic Press, New York.
Okuda, T., and Ito, Y., 1982, Biosynthesis and mutasynthesis of aminoglycoside antibiotics, in Aminoglycoside Antibiotics ( H. Umezawa and I. R. Hooper, eds.), pp. 111–203, Springer-Verlag, Berlin.
Omura, S., and Tanaka, Y., 1984, Biochemistry, regulation and genetics of macrolide production, in Macrolide Antibiotics ( S. Omura, ed.), pp. 199–259, Academic Press, New York.
Perlman, D., Otani, S., Perlman, K. L., and Walker, J. E., 1973, 3-Hydroxy-4-methylkynurenine as an intermediate in actinomycin biosynthesis, J. Antibiot. 26: 289.
Vater, J., 1990, Gramicidin S synthetase, in Biochemistry of Peptide Antibiotics (H. Kleinkauf and H. von Döhren, eds.), pp. 33–55, de Gruyter, Berlin.
Walker, J. B., 1975, Pathways of biosynthesis of guanetidated inositol moieties of streptomycin and bluensomycin, Methods Enzymol. 43: 429.
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Lancini, G., Parenti, F., Gallo, G.G. (1995). Biosynthesis and Genetics of Antibiotic Production. In: Antibiotics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9200-3_6
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DOI: https://doi.org/10.1007/978-1-4757-9200-3_6
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