Antibiotics pp 85-106 | Cite as

Resistance of Microorganisms to Antibiotics

  • Giancarlo Lancini
  • Francesco Parenti
  • Gian Gualberto Gallo


This chapter is composed of three independent but integrated parts. In the first one we describe the modifications present in the resistant bacterial cell with respect to the corresponding susceptible bacterial cell. This topic is closely correlated to the chapter on mechanism of action. In the second part we describe the possible localizations and modes of transmission of the genetic determinants of resistance. The approach applied is a systematic presentation of the different types of resistance mechanisms.


Resistant Cell Resistant Mutant Clavulanic Acid Resistant Bacterium Bacillary Dysentery 
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Further Reading

Chapter 4. Resistance of Microorganisms to Antibiotics

  1. Bryan, L. E. (ed.), 1984, Antimicrobial Drug Resistance, Academic Press, New York. Bryan, L. E. (ed.), 1989, Microbial Resistance to Drugs, Springer-Verlag, Berlin.Google Scholar
  2. Bush, K., 1989, Characterization of ß-lactamases, Antimicrob. Agents Chemother. 33: 259.PubMedCrossRefGoogle Scholar
  3. Bush, K., 1989, Classification of ß-lactamases 1, 2a, 2b, and 2b’, Antimicrob. Agents Chemother. 33: 264.PubMedCrossRefGoogle Scholar
  4. Bush, K., 1989, Classification of 13-lactamases 2c, 2d, 2e, 3, and 4, Antimicrob. Agents Chemother. 33: 271.PubMedCrossRefGoogle Scholar
  5. Foster, T. J., 1983, Plasmid determined resistance to antimicrobial drugs and toxic metal ions in bacteria, Microbiol. Rev., 47: 361.PubMedGoogle Scholar
  6. Franklin, T. J., and Snow, G. A., 1989, Biochemistry of Antimicrobial Action, 4th ed., Chapman and Hall, London.CrossRefGoogle Scholar
  7. Leclerq, R., and Courvalin, P., 1989, Bacterial resistance to macrolide, lincosamide, streptogramin antibiotics by target modification, Antimicrob. Agents Chemother. 35: 735.Google Scholar
  8. Lyon, B. R., and Scurray, R., 1987, Antimicrobial resistance in S. aureus: Genetic basis, Microbiol. Rev., 51: 88.Google Scholar
  9. Quesnel, L. B., 1990, Resistance and tolerance to antimicrobial drugs, in Comprehensive Google Scholar
  10. Medicinal Chemistry,Vol. 2 (P. G. Sammes, ed.), pp. 89–122, Pergamon Press, Oxford. Russel, A. D., and Chopra, I, 1990, Understanding Antibacterial Action and Resistance,Ellis Horwood, Chichester.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Giancarlo Lancini
    • 1
  • Francesco Parenti
    • 2
  • Gian Gualberto Gallo
    • 1
  1. 1.Lepetit Research CenterMarion Merrell Dow Research Institute (MMDRI)GerenzanoItaly
  2. 2.Marion Merrell Dow Europe AGHorgenSwitzerland

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