Antibiotics pp 15-36 | Cite as

The Activity of Antibiotics

  • Giancarlo Lancini
  • Francesco Parenti
  • Gian Gualberto Gallo


The activity of an antibiotic reflects its ability to inhibit microbial growth. While the concept of antibiotic activity appears simple and straightforward, the quantitative expression of antibiotic activity is complex and depends on the assay method and the conditions under which the test microorganism is grown.


Minimal Inhibitory Concentration Solid Medium Minimal Bactericidal Concentration Antibiotic Activity Inoculum Density 
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Further Reading

Chapter 2. The Activity of Antibiotics

  1. Balows, A., Hausler, W. J., Hermann, K. L., lsemberg, H. D., and Shadomy, H. J., 1991, Manual of Clinical Microbiology, 5th ed., American Society for Microbiology, Washington, D.C.Google Scholar
  2. Collins, C. H., and Lyne, P. M., 1984, Microbiological Methods, 5th ed., Butterworths, London.Google Scholar
  3. Hewitt, W., and Vincent, S., 1989, Theory and Application of Microbiological Assay, Academic Press, New York.Google Scholar
  4. Lorian, V. (ed.), 1986, Antibiotics in Laboratory Medicine, 2nd ed., Williams and Wilkins, Baltimore.Google Scholar
  5. Phillips, I. (chairman), 1991, A guide to sensitivity testing, J. Antimicrob. Chemother. 27 (Suppl. D): 1.Google Scholar
  6. Reeves, D. S., Phillips, I., Williams, J. D., and Wise, R., 1978, Laboratory Methods in Antimicrobial Chemotherapy, Churchill, Livingstone, Edinburgh.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Giancarlo Lancini
    • 1
  • Francesco Parenti
    • 2
  • Gian Gualberto Gallo
    • 1
  1. 1.Lepetit Research CenterMarion Merrell Dow Research Institute (MMDRI)GerenzanoItaly
  2. 2.Marion Merrell Dow Europe AGHorgenSwitzerland

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