Abstract
The formation of new blood vessels from pre-existing ones, a phenomenon called angiogenesis, is a complicated process that involves the migration, proliferation and organization of endothelial cells. Angiogenesis is virtually absent in the healthy adult organism, restricted to a few conditions including wound healing and the formation of corpo luteum, endometrium, and placenta. In contrast, in certain pathological conditions, angiogenesis is dramatically enhanced, for example, in rheumatoid arthritis, psoriasis, diabetic retinopathy, hemangiomas and in solid tumors (Folkman and Klagsbrun, 1987; Klagsbrun and D’Amore, 1991).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Connolly, D.T., Heuvelman, D.M., Nelson, R., Olander, J.V., Eppley, B.L., Delfino, J.J., Siegel, N.R., Leimgruber, R.M., and Feder, J., 1989, Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis, J. Clin. Invest. 84: 1470.
Ferrara, N., Houck, K.A., Jakernan, L.B., Winer, J., and Leung, D.W., 1991, The vascular endothelial growth factor family of polypeptides, J. Cell. Biochem., 47: 211.
Folkman, J., and Klagsbrun, M., 1987, Angiogenic factors, Science. 235: 442.
Keck, P.J., Hauser, S.D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D.T., 1989, Vascular permeability factor, an endothelial cell mitogen related to PDGF, Science. 246: 1309.
Klagsbrun, M. and D’Amore, P.A., 1991, Regulators of angiogenesis, Annu. Rev. Physiol. 53: 217.
Maglione, D., Guerriero, V., Viglietto, G., Delli Bovi, P., and Persico, M.G., 1991a, Isolation of human placenta cDNA coding for a protein related to the vascular permeability factor, Proc. Natl. Acad. Sci., 88: 9267.
Maglione, D., Guerriero, V., Viglietto, G., Risau, W., Delli Bovi, P., and Persico, M.G., 1991b, P1GF: a new gene coding for a novel human vascular permeability related protein, In: “Growth Factors of the Vascular and Nervous Systems,” C. Lenfant, R. Paoletti, A. Albertini, eds, S. Karger, Basel.
Maglione, D., Guerriero, V., Viglietto, G., Ferraro, M.G., Aprelikova, O., Alitalo, K., Del Vecchio, S., Lei, K.J., Yang Chou, J., and Persico, M.G., 1993a, Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (P1GF), are transcribed from a single gene of chromosome 14, Oncogene, 8: 925.
Maglione, D., Guerriero, V., Rambaldi, M., Russo, G., and Persico, M.G., 1993b, Translation of the placenta growth factor mRNA is severely affected by a small open reading frame localized in the 5’ untranslated region, Growth Factors. 8: 141.
Risau, W., 1990, Angiogenic growth factors, Prog. Growth Factor Res. 2: 71.
Shweiki, D., Itin, A., Soffer, D., and Keshet, E., 1992, Vascular endothelial growth factor induce by hypoxia may mediate hypoxia-initiated angiogenesis, Nature. 259: 843.
Strick, D.M., Waycaster, R.L., Montani, J.P., Gay, W.J., and Adair, T.H., 1991, Morphometric measurements of chorioallantoic membrane vascularity: effects of hypoxia and hyperoxia, Am. J. Physiol. 260: 1385.
Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, Fiddes, J.C., and Abrahams, J.A., 1991, The human gene for vascular endothelial growth factor, J. Biol. Chem. 266: 11947.
Von Heijene, G., 1986, A new method for predicting signal sequence cleavage sites., Nucl. Acids Res., 14: 4683.
Westermark, B., and Heldin, C.H., 1991, Platelet-derived growth factor in autocrine transformation, Cancer Res. 51: 5087.
Yang, E.Y. and Moses, H.L., 1991, Trasforming growth factor betal-induce change in cell migration, proliferation, and angiogenesis in the chorioallantoic membrane, J. Cell. Biol., 111: 731.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Maglione, D., Persico, M.G. (1994). P1GF: Placenta Derived Growth Factor. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_9
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9188-4_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9190-7
Online ISBN: 978-1-4757-9188-4
eBook Packages: Springer Book Archive