P1GF: Placenta Derived Growth Factor
The formation of new blood vessels from pre-existing ones, a phenomenon called angiogenesis, is a complicated process that involves the migration, proliferation and organization of endothelial cells. Angiogenesis is virtually absent in the healthy adult organism, restricted to a few conditions including wound healing and the formation of corpo luteum, endometrium, and placenta. In contrast, in certain pathological conditions, angiogenesis is dramatically enhanced, for example, in rheumatoid arthritis, psoriasis, diabetic retinopathy, hemangiomas and in solid tumors (Folkman and Klagsbrun, 1987; Klagsbrun and D’Amore, 1991).
KeywordsVascular Endothelial Growth Factor Human Placenta Vascular Permeability Factor VEGF Gene Amino Acid Stretch
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