Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis

  • Peter J. Polverini
Part of the NATO ASI Series book series (NSSA, volume 263)


The processes of tissue regeneration and repair, the cyclical proliferation of the nutrient-rich endometrial lining in preparation for implantation of the fertilized egg; and the complex developmental program that characterizes embryogenesis are biological processes that are strictly dependent on the rapid yet temporary ingrowth of new capillary blood vessels. In contrast, disorders such as neoplasia, proliferative vascular lesions, rheumatoid arthritis and psoriasis, and glaucoma are all characterized by disregulated angiogenesis. The mechanisms underling inappropriate neovascularization have been the subject of considerable investigation. Although there is ample evidence implicating the “overproduction” of normal and/or aberrant forms of angiogenic mediators in the pathogenesis of several well characterized disorders, only recently has attention been given to the role of naturally occurring inhibitors of angiogenesis and the consequences that result from a deficiency in the production of one or more of these “angiostatic” mediators (Moses and Langer, 1991a; Bouck, 1990 and 1993; DiPietro and Polverini, 1993, in press). This report will describe recent studies that support the assertion that angiogenesis is a process that is dependent upon the coordinate production of growth stimulatory and inhibitory molecules and that any disruption in this finely tuned regulatory circuit can result in the development of a number of diseases now classified as “angiogenesisdependent”.


Tumor Suppressor Gene Corneal Neovascularization Cortisone Acetate Chick Chorioallantoic Membrane Capillary Blood Vessel 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Peter J. Polverini
    • 1
  1. 1.Section of Oral Pathology Laboratory of Molecular PathologyUniversity of Michigan School of DentistryAnn ArborUSA

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