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Angiogenesis pp 15–28Cite as

Endothelial Cell Heterogeneity and Organ — Specificity

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Part of the book series: NATO ASI Series ((NSSA,volume 263))

Abstract

Endothelial cell (EC) biology and physiology play a prominent role in studying angiogenesis, i.e. the establishment of new blood vessels from existing ones. According to current perceptions, major features of the angiogenic cascade involve mainly EC-related phenomena such as dissolution of the subendothelial basement membrane, migration of the EC, and formation of a new vessel lumen by establishing tight interendothelial cell contacts. Angiogenesis in vivo occurs primarily at the level of the microvasculature (capillaries, arterioles, venules) and yet most in vitro models have convincingly employed EC isolated from large vessels. Such seemingly discordant approaches raise the question whether EC derived from different vascular beds can be used interchangeably to study common “vascular” phenomena. Over the past few years a large body of experimental findings has been accumulated to the effect that “an EC is not an endothelial cell is not an endothelial cell”1. Rather, EC phenotypic and functional diversity is differentially regulated by a plethora of microenvironmental and/or hemodynamic cues.

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Authors and Affiliations

  1. Dept. Biology, Univ. Wisconsin Med School, Milwaukee Clinical Campus, University, Milwaukee, WI, USA

    Peter I. Lelkes, Vangelis G. Manolopoulos & Dawn Chick

  2. Marquette, USA

    Vangelis G. Manolopoulos & Brian R. Unsworth

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  1. Peter I. Lelkes
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  2. Vangelis G. Manolopoulos
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Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Torino Medical School, Torino, Italy

    Pietro M. Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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Lelkes, P.I., Manolopoulos, V.G., Chick, D., Unsworth, B.R. (1994). Endothelial Cell Heterogeneity and Organ — Specificity. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_3

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