Anti-Tumor Effects of GBS Toxin are Caused by Induction of a Targeted Inflammatory Reaction
Group B Streptococcus is a major pathogen in hospital nurseries in the United States affecting 10,000 neonates each year with the mortality rate of approximately 15%. GBS pneumonia, often called early onset disease, presents with signs of sepsis, granulocytopenia, and respiratory distress and is characterized by pulmonary hypertension and increased vascular permeability and proteinaceous pulmonary edema. After treatment with antibiotic, the neonate is cured of the infection but the symptoms of early onset disease persist which suggests the involvement of an extracellular toxin similar to gram-negative endotoxin shock. These observations led us to analyze both bacteria and media components which could be responsible for the induction of respiratory distress in the neonate.
KeywordsNude Mouse Tumor Vasculature Early Onset Disease Endothelial Receptor Extracellular Toxin
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