Angiogenesis and Fibrin Degradation in Human Breast Cancer
Poorer prognosis and likelihood of metastasis in patients with breast cancer have now been claimed by several groups to be associated with increased vascularity in breast biopsies from these cases (1, 2, 3). Fibrin deposition and lysis is known to occur at the invasive tumour margin of breast cancer where angiogenesis also occurs. Fibrin degradation products (FDP) have been shown previously by us to be angiogenic on the standard test system, the chick chorioallantoic membrane (CAM) (4). Solid fibrin is degraded by plasmin into soluble combinations of the two major components termed D and E, and it is fragment E that is angiogenic (5). Therefore our aim was to develop a method for assessing individual tumour angiogenic activity, and to relate this to tumour vascularity and content of FDP (6).
KeywordsAngiogenic Activity Fibrin Degradation Product Human Atherosclerotic Plaque Chick Chorioallantoic Membrane Aberdeen Royal Infirmary
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