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Tumor Antiangiogenesis: Which Way?

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Angiogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 263))

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Abstract

The presence of neoplastic cells in a normal tissue elicits from the host vascular network a large number of microvessels that sustain tumor growth. Angiogenic capacity is peculiar but not restricted to neoplastic cells;1,2 it appears in the course of neoplastic transformation before the cell population can form a tumor upon transplantation;3,4 it suggests an increased risk of neoplastic transformation when acquired by a cell population normally not angiogenic.5,6 Present knowledge of tumor angiogenesis sustains the belief of many investigators that antiangiogenesis treatment of a tumor bearing host might arrest or effectively impair growth of primary as well as metastatic neoplasia. Fig. 1 depicts one observation that supports this belief. In this model a very rapid growth consistently occurs as soon as the vessels colonize the neoplastic cell population, thus, it seems reasonable to expect growth arrest or impairment if angiogenesis is blocked. What guide does present knowledge of angiogenesis offer in searching for an effective antiangiogenesis treatment? An effort to address this question is made here in an environment most suitable for speculation.

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Author information

Authors and Affiliations

  1. Department of Biomedical Sciences, University of Torino, Via Santena, 7, 10126, Torino, Italy

    Pietro M. Gullino

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  1. Pietro M. Gullino
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Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Torino Medical School, Torino, Italy

    Pietro M. Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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© 1994 Springer Science+Business Media New York

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Gullino, P.M. (1994). Tumor Antiangiogenesis: Which Way?. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_21

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  • DOI: https://doi.org/10.1007/978-1-4757-9188-4_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9190-7

  • Online ISBN: 978-1-4757-9188-4

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