Angiogenesis pp 171-181 | Cite as

Endothelial Plasminogen Activators and Matrix Metalloproteinases in Fibrinolysis and Local Proteolysis

  • Victor W. M. van Hinsbergh
  • Roeland Hanemaaijer
  • Pieter Koolwijk
Part of the NATO ASI Series book series (NSSA, volume 263)


Fibrin is a temporary matrix, which is formed after wounding of a blood vessel and when plasma leaks from blood vessels forming a fibrous exudate, often seen in areas of inflammation and in tumors.1 The fibrin matrix acts as a barrier preventing further blood loss, and provides a scaffolding in which new microvessels can infiltrate during wound healing. A proper timing of the outgrowth of microvessels, angiogenesis, as well as the subsequent (partial) disappearance of these vessels is essential to ensure adequate wound healing and to prevent the formation of scar tissue. It is generally believed that plasminogen activators play an important role in the migration of leukocytes and endothelial cells, and in the dissolution of the fibrin matrix.2,3 Plasminogen activators are serine proteases, which enzymatically convert the zymogen plasminogen into the active protease plasmin, the prime protease that degrades fibrin.


Plasminogen Activator Human Endothelial Cell Fibrinolytic Activity Plasminogen Activator Inhibitor Type Plasminogen Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Victor W. M. van Hinsbergh
    • 1
  • Roeland Hanemaaijer
    • 1
  • Pieter Koolwijk
    • 1
  1. 1.Gaubius Laboratory IVVO-TNOLeidenThe Netherlands

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