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Angiogenesis pp 1–8Cite as

Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage ?

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Part of the NATO ASI Series book series (NSSA,volume 263)

Abstract

Endothelial cells (EC) play a leading role in the modelling of blood vessels. In the embryo they form the blueprint of the vascular tree, the differentiation of which occurs by regionalization of EC properties and apposition of appropriate wall cells. In the adult animal, the turnover of EC, an extremely slow process, accelerates only in a few physiological situations and during tumor progression: formerly quiescent EC becoming reactivated, start multiplying, rupture their basement membrane and migrate. This process, termed angiogenesis (see Folkman, 1974) has been extensively studied at the cellular and biochemical levels. The interplay of growth factors involved either in maintenance of the quiescent state or in reactivation has been investigated. De novo appearance of EC during ontogeny is less well understood. This process, designated vasculogenesis (Pardanaud et al. 1987; Risau and Lemon, 1988) has been partly circumscribed but the cellular, biochemical and molecular events underlying it are still largely elusive.

Keywords

  • Chick Embryo
  • Hemopoietic Stem Cell
  • Hemopoietic Cell
  • Avian Embryo
  • Blood Island

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Author information

Authors and Affiliations

  1. Institut d’Embryologie cellulaire et moléculaire, CNRS et du Collège de France, 49bis, av. de la Belle Gabrielle, 94736, Nogent s/Marne, cédex, France

    Françoise Dieterlen-Lièvre, Dominique Luton & Luc Pardanaud

Authors
  1. Françoise Dieterlen-Lièvre
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  2. Dominique Luton
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  3. Luc Pardanaud
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Editor information

Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Torino Medical School, Torino, Italy

    Pietro M. Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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© 1994 Springer Science+Business Media New York

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Dieterlen-Lièvre, F., Luton, D., Pardanaud, L. (1994). Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage ?. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_1

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  • DOI: https://doi.org/10.1007/978-1-4757-9188-4_1

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