Angiogenesis pp 149-170 | Cite as

Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis

  • Michael S. Pepper
  • Jean-Dominique Vassalli
  • Lelio Orci
  • Roberto Montesano
Part of the NATO ASI Series book series (NSSA, volume 263)


The blood vascular system is composed of a series of vessels of varying structural complexity. All blood vessels are lined by a monolayer of quiescent endothelial cells, which provide a structural and functional barrier between circulating blood and the surrounding tissues. In their simplest form, as represented by capillaries, blood vessels are surrounded by a basement membrane composed of type IV collagen, laminin, proteoglycans and other glycoproteins. A second cell type, namely the pericyte, is often associated with the capillary wall.


Endothelial Cell Vascular Endothelial Growth Factor Basic Fibroblast Growth Factor Microvascular Endothelial Cell Endothelial Cell Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Michael S. Pepper
    • 1
  • Jean-Dominique Vassalli
    • 1
  • Lelio Orci
    • 1
  • Roberto Montesano
    • 1
  1. 1.Department of MorphologyUniversity Medical CenterGeneva 4Switzerland

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