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Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth

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Angiogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 263))

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Abstract

The basement membrane is a thin extracellular matrix which underlies endothelial cells in vessels and forms a barrier to the passage of macromolecules and cells (Martin et al, 1988). Basement membranes also provide structural support and are very biologically active (Kleinman et al, 1987; Beck et al, 1990). The major and constant components of basement membranes include laminin, collagen IV, entactin, heparan sulfate proteoglycan and various growth factors (Martin et al, 1988; Vukicevic et al, 1992). These components interact with each other to form a highly elastic and organized structure.

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© 1994 Springer Science+Business Media New York

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Kleinman, H.K., Grant, D.S., Kibbey, M.C. (1994). Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_17

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  • DOI: https://doi.org/10.1007/978-1-4757-9188-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9190-7

  • Online ISBN: 978-1-4757-9188-4

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