Angiogenesis pp 135-141 | Cite as

Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth

  • Hynda K. Kleinman
  • Derrick S. Grant
  • Maura C. Kibbey
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

The basement membrane is a thin extracellular matrix which underlies endothelial cells in vessels and forms a barrier to the passage of macromolecules and cells (Martin et al, 1988). Basement membranes also provide structural support and are very biologically active (Kleinman et al, 1987; Beck et al, 1990). The major and constant components of basement membranes include laminin, collagen IV, entactin, heparan sulfate proteoglycan and various growth factors (Martin et al, 1988; Vukicevic et al, 1992). These components interact with each other to form a highly elastic and organized structure.

Keywords

Basement Membrane Melanoma Cell Neurite Outgrowth Basement Membrane Component Avian Malaria Parasite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Hynda K. Kleinman
    • 1
  • Derrick S. Grant
    • 1
  • Maura C. Kibbey
    • 1
  1. 1.National Institute for Dental ResearchNational Institutes of HealthBethesdaUSA

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