A Novel Laminin Domain Involved in Adhesion of Endothelial Cells
Endothelial cells interact with various cell types and with extracellular matrices; both types of interactions are important for their functional integrity. Most endothelial cells are underlined by a basement membrane, which is a very specialized form of extracellular matrix. It contains several macromolecules present exclusively in it and absent from any other extracellular matrix compartment. These macromolecules are: type IV collagen, laminin, entactin/nidogen, perlekan(a form of heparan sulfate proteoglycan), chondroitin sulfate proteoglycan. Most of them exist in various isoforms which interact in complicated ways to form the heteropolymeric and heterogeneous structure which is defined as basement membranel.
KeywordsControl Peptide Chondroitin Sulfate Proteoglycan Endothelial Cell Motility Outer Globule Peptide AC15
Unable to display preview. Download preview PDF.
- 1.A.S.Charonis and E.C.Tsilibary, Assembly of Basement Membrane Proteins, in “Organization and Assembly of Plant and Animal Extracellular Matrix”, R.P.Mecham, ed., Academic Press, New York (1990).Google Scholar