Angiogenesis pp 111-118 | Cite as

Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins

  • Theodosia A. Kalfa
  • Mary E. Gerritsen
  • Effie C. Tsilibary
Part of the NATO ASI Series book series (NSSA, volume 263)


Diabetic retinopathy is characterized by microaneyrisms derived from vessels which have selectively lost their pericytes and demonstrate focal proliferation of endothelial cells. The proliferation of retinal endothelial cells and the pericytic degeneration followed by replacement with pericytic “ghosts” is an almost invariable and early feature of diabetic retinopathy 1.


Diabetic Retinopathy Glomerular Basement Membrane Aldose Reductase Inhibitor Retinal Endothelial Cell Retinal Cell Type 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Theodosia A. Kalfa
    • 1
  • Mary E. Gerritsen
    • 2
  • Effie C. Tsilibary
    • 1
  1. 1.Department of Laboratory Medicine and PathologyUniversity of Minnesota Medical SchoolUSA
  2. 2.Miles LaboratoriesWest HavenUSA

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