Angiogenesis pp 103-109 | Cite as

Interactions between Oxidized Lipoprotein (a) [Lp(a)], Monocytes and Endothelial Cells

  • Mahmoud Ragab
  • Periasamy Selvaraj
  • Demetrios S. Sgoutas
Part of the NATO ASI Series book series (NSSA, volume 263)


Lipoprotein (a) [Lp(a)] is a subclass of low density lipoproteins (LDL) whose elevated blood concentrations constitute an independent risk factor for coronary artery disease (CAD). Lipoprotein (a) derives its uniqueness from an appendage, apolipoprotein (a), which is linked to the apolipoprotein B-100 portion of LDL. Apolipoprotein (a) has been found to display a remarkable homology with plasminogen. This homology has lead to suggestions that there may be competition between Lp(a) and plasminogen for binding to fibrin, and to cell membranes. Consequently, much attention has been paid to interactions between fibrin, Lp(a), and plasmin and to the linkage of thrombosis and atherogenesis.

In contrast, this study draws attention at the cholesterol rich component of Lp(a) which is identical to LDL, investigates its oxidation and the role of oxidized Lp(a) in activating resident intimai macrophages. It provides evidence that oxidatively modified Lp(a), enhanced the expression of surface antigens on U937 cells and stimulated adhesion of U937 cells to cultured endothelial cells. These results suggest that oxidatively modified Lp(a) like oxidized LDL behaves as an inducer of differentiation, adhesion and activation of monocytes, leading to the hypothesis that oxidized Lp(a) may play an important role in atherogenesis, and CAD.


Endothelial Cell Fatty Acid Composition U937 Cell Clot Lysis U937 Monocytic Cell 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mahmoud Ragab
    • 1
  • Periasamy Selvaraj
    • 1
  • Demetrios S. Sgoutas
    • 1
  1. 1.Department of Pathology and Laboratory MedicineEmory University School of MedicineAtlantaUSA

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