The Proliferative Effect of Substance P on Capillary Endothelial Cells is Mediated by Nitric Oxide
Under physiological circumstances the ability of a given tissue to produce a neovascular response is under strict control, i.e. the balance between factors and events favoring or interfering with neovascular growth is in equilibrium. Modification of the normal cell/cell and cell/matrix boundaries, which maintain tubular morphology of the endothelium at the postcapillary level, is a prerequisite for capillary endothelial cell mobilization and proliferation to constitute a neovascular response.
KeywordsNitric Oxide Nitric Oxide Thymidine Incorporation Guanylate Cyclase Capillary Endothelial Cell
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