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Angiogenesis pp 475–492Cite as

Clinical Trials of Angiogenesis-Based Therapies: Overview and New Guiding Principles

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Part of the book series: NATO ASI Series ((NSSA,volume 298))

Abstract

Angiogenesis, new blood vessel growth, is a “common denominator” pathologic feature in many serious diseases, including cancer, coronary artery disease, stroke, blindness, arthritis, and more than one dozen other major conditions. Against the backdrop of largely unsatisfactory current treatments for these conditions, a new form of medical therapy aimed at controlling angiogenesis is emerging after three decades of basic scientific research. In simplest terms, angiogenesis modulating drugs restore growth control over the vascular system — by either turning “on” or turning “off” angiogenesis. A number of angiogenesis-modulating compounds, both stimulators and inhibitors, are currently in clinical trials in the United States, Canada and Europe. The reality of these trials, and some exciting early positive results, heralds an exciting era of medical therapy for the new millennium, and offers renewed hope for patients suffering from currently incurable diseases such as cancer.

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Author information

Authors and Affiliations

  1. The Angiogenesis Foundation, P.O. Box 383011, Cambridge, Massachusetts, 02238, USA

    William W. Li M.D., Vincent W. Li M.D., Richard Casey M.D., Erwin A. Kruger, Andrew Lee, Yee-Li Sun, Christopher A. Bonar V.M.D. & Shawna Cornelius

  2. The Angiogenesis Foundation, Europe, 113 Marathonodromon Street, 15452, Athens, Greece

    Dimitris Tsakayannis M.D.

Authors
  1. William W. Li M.D.
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  2. Vincent W. Li M.D.
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  3. Richard Casey M.D.
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  4. Dimitris Tsakayannis M.D.
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  5. Erwin A. Kruger
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  6. Andrew Lee
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  7. Yee-Li Sun
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  8. Christopher A. Bonar V.M.D.
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Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

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© 1998 Springer Science+Business Media New York

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Li, W.W. et al. (1998). Clinical Trials of Angiogenesis-Based Therapies: Overview and New Guiding Principles. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_43

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  • DOI: https://doi.org/10.1007/978-1-4757-9185-3_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9187-7

  • Online ISBN: 978-1-4757-9185-3

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