Basement Membrane Biosynthesis as a Biochemical Index of Angiogenesis in Chick Chorioallantoic Membrane

  • Nikos E. Tsopanoglou
  • Michael E. Maragoudakis
Part of the NATO ASI Series book series (NSSA, volume 298)


The chorioallantoic membrane (CAM) of the chick is formed by fusion of the somatic mesoderm of the chorion with the splachnic mesoderm of the allantois during the 4th to 5th day of embryonic development. After 6 days of incubation, the CAM is covering a surface area of approximately 6 cm2. By day 10, and extending to day 14, mean surface area of the CAM is approximately 65 cm2. This expansion of CAM is accompanied by an increased complexity of the patterns of capillary microvessels. The number of capillary vessels per square centimetre is increased about 150% from day 7 to day 12 and the intercapillary distances have been reduced about 40% during the same period (1). This highly vascularized membrane serves as the first respiratory system of the avian.


Vascular Density Collagenous Protein Chorioallantoic Membrane Cortisone Acetate Chick Chorioallantoic Membrane 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Nikos E. Tsopanoglou
    • 1
  • Michael E. Maragoudakis
    • 1
  1. 1.Department of Pharmacology, Medical SchoolUniversity of PatrasPatrasGreece

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