Angiogenesis pp 407-414 | Cite as

Tumor Vascularity, Hypoxia, and Malignant Progression in Solid Neoplasms

  • Michael Höckel
  • Karlheinz Schlenger
  • Billur Aral
  • Uwe Schäffer
  • Wolfgang Weikel
Part of the NATO ASI Series book series (NSSA, volume 298)


Malignant progression designates the biologic process which transforms a phenotypically normal cell fixed and cooperating within a tissue into a disseminated therapy-resistant lethal disease. In clinical terms this process consists of three major steps (Fig. 1):
  • () the transition from regulated to deregulated cell proliferation,

  • () the emerging ability of the neoplastic cell collectives to induce angiogenesis and to invade other tissues,

  • () the development of metastases and of resistance towards anti-tumor therapies.


Cervical Cancer Uterine Cervix Tumor Hypoxia Malignant Progression Tumor Oxygenation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Michael Höckel
    • 1
  • Karlheinz Schlenger
    • 1
  • Billur Aral
    • 1
  • Uwe Schäffer
    • 1
  • Wolfgang Weikel
    • 1
  1. 1.Dept of Ob/GynUniversity of MainzMainzGermany

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