Abstract
Angiogenesis is a processes of new capillary formation from preexisting vessels in response to cytokine stimuli. It involves the breakdown of the surrounding basement membrane, proliferation and migration of the endothlial cells which comprise the vessel wall toward the angiogenic stimulus, and subsequent secretion of basement membrane, leading to the formation of a new capillary branch. This process is dynamic, rather than occurring in discrete steps. Angiogenesis is necessary for many physiological (development, reproductive cycle) and pathological (tumor growth and metastasis, wound healing) processes. Previously, several investigators have explored the use of angiogenic agonists in the revascularization of ischemic tissue. We have recently examined in vivo the ability of SIKVAV (a peptide derived from the alpha chain of laminin-1) to revascularize ischemic tissue. In this manuscript, we review the work done with SIKVAV and its role in angiogenesis as it pertains to the revascularization of ischemic tissue.
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Rose, R.W., Morrison, R.C., Magno, M.G., Mannion, J., Kleinman, H.K., Grant, D.S. (1998). The Role of the Laminin Peptide SIKVAV in the Revascularization of Ischemic Tissue. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_34
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DOI: https://doi.org/10.1007/978-1-4757-9185-3_34
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