Angiogenesis in the Heart and Skeletal Muscle — Models for Capillary Growth

  • O. Hudlicka
  • S. Egginton
  • M. D. Brown
Part of the NATO ASI Series book series (NSSA, volume 298)


Growth of vessels under physiological circumstances in adults appears only in female reproductive organs, but can be elicited by endurance training in skeletal and sometimes in cardiac muscle (for review see Hudlicka et al., 1992; Hudlicka and Brown, 1996). However, to achieve an increase in capillary supply of 20% in skeletal muscles takes 5–8 weeks of very intensive endurance training in man (Andersen and Henriksson, 1977), and usually about 12 weeks in animals such as rat (see Gute et al., 1994). Endurance training is obviously linked with a long-term increase in activity of skeletal muscles and hence overload resulting sometimes but not always, in muscle hypertrophy. It also results in an increase in the capacity of the whole vascular bed (Snell et al., 1987) due to high blood flow in contracting muscles.


Endurance Training Tibialis Anterior Coronary Blood Flow Extensor Digitorum Longus Capillary Density 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • O. Hudlicka
    • 1
  • S. Egginton
    • 1
  • M. D. Brown
    • 2
  1. 1.Department of PhysiologyUniversity of BirminghamBirminghamUK
  2. 2.Department of Sport and Exercise SciencesUniversity of BirminghamBirminghamUK

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