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Angiogenesis pp 213–221Cite as

Angiogenic Polypeptides in Breast Cancer: Expression of Mrna’s in Primary Human Tumours, MCF-7 Cell Transfection and Xenograft Models

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Part of the book series: NATO ASI Series ((NSSA,volume 298))

Abstract

Screening of 84 primary human breast carcinomas for the mRNA expression of seven angiogenic polypeptides showed that the most commonly expressed and/or the most highly expressed when compared to normal breast tissue were vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor/thymidine Phosphorylase (PDECGF/TP)1. The neurokines midkine (MK) and pleiotrophin were also fairly commonly expressed in tumour but not normal tissue (unpublished data from this group and ref. 1).

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References

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Author information

Authors and Affiliations

  1. Molecular Angiogenesis Group, USA

    Hua-Tang Zhang, Rangana Choudhuri, Prudence AE Scott, Lyna Zhang, Sandra Donnini, Rhys T. Jagger, Hock-Ye Chan & Roy Bicknell

  2. Growth Factor Group, Imperial Cancer Research Fund, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, OX3 9DU, UK

    Kenneth Smith & Adrian L. Harris

  3. Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts, UK

    Sandra Peak

  4. Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK

    Lyna Zhang & Margaret C. P. Rees

  5. Department of Pharmacology, University of Florence, 50134, Florence, Italy

    Marina Ziche, Lucia Morbidelli & Sandra Donnini

Authors
  1. Hua-Tang Zhang
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  2. Rangana Choudhuri
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  3. Prudence AE Scott
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  4. Lyna Zhang
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  5. Marina Ziche
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  6. Lucia Morbidelli
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  7. Sandra Donnini
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  8. Rhys T. Jagger
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  9. Hock-Ye Chan
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  10. Kenneth Smith
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  11. Sandra Peak
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  12. Margaret C. P. Rees
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  13. Adrian L. Harris
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  14. Roy Bicknell
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Editor information

Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

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Zhang, HT. et al. (1998). Angiogenic Polypeptides in Breast Cancer: Expression of Mrna’s in Primary Human Tumours, MCF-7 Cell Transfection and Xenograft Models. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_23

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  • DOI: https://doi.org/10.1007/978-1-4757-9185-3_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9187-7

  • Online ISBN: 978-1-4757-9185-3

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