Angiogenesis pp 179-184 | Cite as

Lesional Levels of Endothelial Cell Stimulating Angiogenesis Factor (ESAF) and Vascular Endothelial Cell Stimulating Angiogenesis Factor (VEGF) are Elevated in Psoriasis

  • B. McLaughlin
  • M. Bushan
  • J. B. Weiss
  • C. Griffiths
Part of the NATO ASI Series book series (NSSA, volume 298)


Psoriasis is a common, disabling, chronic dermatosis that affects approximately 2% of the UK population. Although genetically determined, the usual age of onset of the first lesions is between the ages of 15 and 30. The redness of the psoriatic plaque is dermal hyperaemia which results from dilation and increased tortuosity of capillaries in elongated dermal papillae. Early microvascular changes are amongst the earliest signs of the development of new psoriatic plaques[l]. Thus, psoriasis may be considered as an example of an angiogenic disease.


Dermal Papilla Psoriatic Skin Vascular Endothelial Cell Growth Factor Chronic Plaque Psoriasis Psoriatic Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • B. McLaughlin
    • 1
  • M. Bushan
    • 2
  • J. B. Weiss
    • 1
  • C. Griffiths
    • 2
  1. 1.Wolfson Angiogenesis Unit, Rheumatic Diseases Centre, Hope Hospital, CSBUniversity of ManchesterManchesterUK
  2. 2.Department of DermatologyHope HospitalManchesterUK

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