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Angiogenesis pp 165–178Cite as

Structural Studies on Angiogenin, a Protein Implicated in Neovascularization during Tumour Growth

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Part of the book series: NATO ASI Series ((NSSA,volume 298))

Abstract

Angiogenesis, the formation of new blood vessels, is an essential part of normal physiological processes such as embryonic growth, wound healing, and the cyclical development of the uterine endometrium. It also occurs in a variety of pathological conditions including arthritis, diabetic retinopathy, and tumour growth (Folkman and Cotran, 1976). Early observers had noted a proliferation of blood vessels in the vicinity of such tumours (see Vallee et al., 1985), and it was later proposed by Folkman (1971) that these tumours are totally dependent on angiogenesis for growth beyond a diameter of 1–2 mm. Angiogenesis is also thought to be a prerequisite for the development of metastases since it provides the means whereby cells disseminate from the original primary tumour.

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Author information

Authors and Affiliations

  1. Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK

    K. Ravi Acharya, Demetres D. Leonidas & Anastassios C. Papageorgiou

  2. Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Nello Russo & Robert Shapiro

  3. Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Robert Shapiro

Authors
  1. K. Ravi Acharya
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  2. Demetres D. Leonidas
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  3. Anastassios C. Papageorgiou
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  4. Nello Russo
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  5. Robert Shapiro
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Editor information

Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

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© 1998 Springer Science+Business Media New York

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Acharya, K.R., Leonidas, D.D., Papageorgiou, A.C., Russo, N., Shapiro, R. (1998). Structural Studies on Angiogenin, a Protein Implicated in Neovascularization during Tumour Growth. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_19

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  • DOI: https://doi.org/10.1007/978-1-4757-9185-3_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9187-7

  • Online ISBN: 978-1-4757-9185-3

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