Angiogenesis pp 149-155 | Cite as

Angiogenesis in Atherosclerosis: Possible Roles for Vascular Endothelial Cell Growth Factor, Endothelial Cell Stimulating Angiogenesis Factor and Soluble E-Selectin

  • J. B. Weiss
  • A. Blann
  • Jun-Ling Li
  • C. N. McCollom
  • A. Bate
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

Endothelial cell injury is believed to be an important early step in the pathogenesis of atherosclerosis, and there is evidence of endothelial cell dysfunction in the risk factors for this disease[1–4]. It follows that if there is generalsied endothelial cell destruction in atherosclerosis then there must also be a proportional increase in repair if the intima is to avoid being de-endothelialised. A further vascular consequence of atherosclerosis is angiogenesis of the vasa vasorum within the arterial media and adventicia, in response to the ischaemia following arteriole occlusion. Such a consequence may be dangerous as angiogenesis in neovascularising blood vessels affected by atherosclerosis can cause atheroma to rupture or thrombose, or cause vascular spasm.

Keywords

Peripheral Vascular Disease Ischaemic Heart Disease Vascular Endothelial Cell Growth Factor Endothelial Cell Damage Large Vessel Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • J. B. Weiss
    • 1
  • A. Blann
    • 2
  • Jun-Ling Li
    • 3
  • C. N. McCollom
    • 2
  • A. Bate
    • 1
  1. 1.Wolfson Angiogenesis Unit, Rheumatic Diseases Centre, Hope HospitalUniversity of ManchesterManchesterUK
  2. 2.Department of SurgerySouth Manchester University HospitalManchesterUK
  3. 3.Thrombosis, Haemostsis and Vascular Biology Unit, The City HospitalUniversity Department of MedicineBirminghamUK

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