Angiogenesis pp 137-147 | Cite as

Role of Fibroblast Growth Factor -2 and Endothelial Cell Stimulating Angiogenic Factor (ESAF) in Capillary Growth in Skeletal Muscles Exposed to Long-Term High Activity

  • M. D. Brown
  • H. Walter
  • O. Hudlicka
  • F. M. Hansen-Smith
  • J. B. Weiss
Part of the NATO ASI Series book series (NSSA, volume 298)


Angiogenesis, the development of new blood vessels, is a process controlled by many different mediators, of which different growth factors have been considered to be key regulators. In particular, fibroblast growth factors (FGFs) are known to be involved in angiogenesis in many pathological situations e.g. tumours (Folkman and Klagsbrun, 1987), wound healing (Broadley, Aquino, Woodward, Buckley-Sturrock, Sato, Rifkin and Davidson, 1989), inflammatory conditions (D’Amore, 1992), growth of collateral vessels in ischaemic heart (Schaper, Sharma, Quinkler, Markert, Wünsch and Schaper, 1990) and skeletal muscle (Yang, Deschenes, Ogilvie and Terjung, 1996). However, FGFs do not appear to cause proliferation of endothelial cells in uninjured tissue (D’Amore, 1990) and it has therefore not been established whether they play a role in angiogenesis under normal physiological conditions when the microvascular bed is undamaged. During development, FGFs may be involved in vasculogenesis in the heart (Tomanek, Haung, Suvarna, O’Brien, Ratajska and Sandra, 1996), but in skeletal muscle, angiogenesis during postnatal growth does not seem to be associated with basic fibroblast growth factor FGF-2 (Hansen-Smith, Morris and Joswiak, 1992).


Skeletal Muscle Tibialis Anterior Basic Fibroblast Growth Factor Extensor Digitorum Longus Extensor Digitorum Longus Muscle 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • M. D. Brown
    • 1
  • H. Walter
    • 2
  • O. Hudlicka
    • 2
  • F. M. Hansen-Smith
    • 3
  • J. B. Weiss
    • 4
  1. 1.School of Sport and Exercise SciencesUniversity of BirminghamUK
  2. 2.Dept. of PhysiologyUniversity of BirminghamUK
  3. 3.Dept. of Biological SciencesOakland UniversityRochesterUSA
  4. 4.Wolfson Angiogenesus Unit, Department of RheumatologyHope HospitalSalfordUK

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